KOLKATA, India – Nov. 14, 2026 – PRLog — Magnesium plays an essential role in more than 300 enzymatic reactions in the human body, including those associated with muscle function, nerve signalling, cardiovascular health and energy metabolism. Despite its importance, conventional magnesium supplements can present challenges related to absorption, solubility and gastrointestinal tolerance. Advanced liposomal delivery offers a promising approach to address these formulation challenges.
With its LipoEdge Liposomal Technology, West Bengal Chemical Industries Limited (WBCIL) has developed an advanced Liposomal Magnesium formulation, supported by scientific research and comprehensive physicochemical characterisation.
The research, published in the International Journal of Development Research in August 2025, highlights the use of 75% sunflower lecithin as the phospholipid source. The resulting formulation demonstrated a total phospholipid content of 93%, comprising 82.05% phosphatidylcholine and 10.82% phosphatidylethanolamine. These components contribute to the structural integrity of the liposomal bilayer.
One of the key findings was an encapsulation efficiency of 80.03%, indicating effective entrapment of magnesium within the liposomal structure. Further analysis recorded an average particle size of 212.3 nm, a polydispersity index (PDI) of 0.3454 and a zeta potential of -34.83 mV, supporting favourable dispersion characteristics.
Stability was another important focus of the research. During six months of accelerated storage at 40°C ± 2°C and 75% ± 5% relative humidity, encapsulation efficiency remained within 80–81%, with minimal magnesium leakage. Even after exposure to 105°C for four hours, the formulation retained 79% encapsulation efficiency, demonstrating encouraging structural resilience under the tested conditions.
These findings add to the scientific understanding of liposomal magnesium benefits, particularly the potential advantages of phospholipid-
For nutraceutical and pharmaceutical ingredient developers, LipoEdge focuses on research-led liposomal ingredient development, with attention to encapsulation efficiency, particle characteristics and stability.
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Scientific Reference
Gupta Banerjee, P., Paul, A., Chakraborty, A., & Kundu, S. (2025). Superior Formulation Strategy and Advanced Characterisation of Liposomal Magnesium: A Novel Approach by WBCIL. International Journal of Development Research, 15(08), 68830–68838.
DOI: https://doi.org/